Preston C. Sprenkle

Preston C. Sprenkle, MD, is an Associate Professor of Urology at Yale School of Medicine, specializing in urologic cancers, particularly prostate cancer. He leads the Urology Research Fellowship and holds roles at the VA Connecticut Healthcare System, including Division Chief of Urology. His research focuses on improving prostate cancer diagnosis and treatment through advanced imaging (e.g., MRI fusion biopsy) and focal therapy to minimize patient morbidity. He chairs the NCCN Prostate Cancer Early Detection Guidelines Committee and co-chairs the Cancer Liaison Committee at the VA.

Education: MD from Columbia University (2004), BA from Stanford University (1998). Residencies and fellowships include New York Presbyterian Hospital and Memorial Sloan Kettering Cancer Center.

Research interests include ablation techniques (e.g., cryoablation, irreversible electroporation), genomic profiling, and machine learning in prostate cancer diagnosis. He leads clinical trials such as the CAPTAIN trial comparing TULSA ablation to radical prostatectomy.

Key awards include multiple Mentor Appreciation Awards and recognition for early career contributions. His work emphasizes personalized treatment plans and reducing treatment side effects.

Grants and funding support his research on MRI technologies and prostate cancer management. He collaborates with institutions like the National Surgery Office and the National Comprehensive Cancer Network.

Labs/Teams: Active in Yale’s Prostate & Urologic Cancers Program and Robotic Surgery initiatives. His team focuses on translational research and clinical innovation.