معرفی
Shanthini Sockanathan is a Professor of Neuroscience at the Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine. Her research focuses on understanding mechanisms underlying neuronal survival and neurodegeneration, particularly through investigation of GDE2 and GDE3 enzymes. These proteins regulate GPI-anchored protein function and are implicated in diseases like Alzheimer’s and ALS. Her lab employs interdisciplinary approaches including in vivo models, iPSC-derived neurons, and advanced imaging techniques.
Research Interests: Her work explores physiological pathways maintaining neuronal viability, with emphasis on GDE enzymes’ roles in neuronal-glial communication, synaptic function, and neurodegenerative pathologies. Recent studies reveal GDE2 disruption mimics ALS/FTD and AD phenotypes in patient samples.
Publications: Over 30 peer-reviewed articles since 2005, focusing on GDE enzymes’ roles in neurodevelopment and disease. Key topics include Wnt signaling, TDP-43 mislocalization, and vascular contributions to neurodegeneration.
Lab Personnel: Current trainees include graduate students (e.g., Damani Sama-Borbon) and postdocs (e.g., Poulomi Banerjee). Former members hold academic and industry positions globally, reflecting her lab’s impactful training.
Positions: Affiliated with Neuroscience, Biochemistry, and Cross-Disciplinary Biomedical Science graduate programs. No current openings advertised.
