Shaji K Chacko

Shaji K Chacko, Ph.D., is an Instructor in the Department of Pediatrics – Nutrition at Baylor College of Medicine, where he leads an independent research laboratory at the USDA/ARS Children's Nutrition Research Center in Houston, Texas. His work focuses on metabolic regulation, particularly glucose production pathways in health and disease.

• BS, Nagpur University (1990)
• MS, Barkatullah University (1992)
• MS, University of Houston, Clear Lake (2000)
• PhD, University of Groningen (2011)

Dr. Chacko's research centers on glucose metabolism, specifically gluconeogenesis and glycogenolysis, using stable isotope tracers and mass spectrometry. His lab investigates metabolic dysfunctions in conditions such as insulin resistance, type 2 diabetes, and post-surgical states, with a strong focus on pediatric and neonatal populations. He also studies total energy expenditure using the doubly labeled water method in free-living subjects.

The 15 most recent publications reflect a consistent focus on metabolic regulation, particularly in insulin resistance, obesity, diabetes, and parenteral nutrition. Key themes include hormonal regulation (e.g., leptin), amino acid metabolism (glycine, BCAA), liver function, and therapeutic interventions like metformin and nutritional supplements. His work frequently involves translational models, including human clinical studies and genetically modified animal models.

Dr. Chacko has not received any explicitly mentioned scientific awards in the provided texts.

He mentors lab members such as Zhensheng Chen (Research Associate) and collaborates extensively with clinicians and scientists, including M.W. Haymond and F. Jahoor. While no specific grants are listed, his research likely involves externally funded projects given the scope and equipment required for stable isotope and mass spectrometry studies. His lab benefits from the state-of-the-art facilities at the Children's Nutrition Research Center, including a metabolic kitchen, greenhouse, and advanced instrumentation.

The Shaji Chacko Lab is embedded within the USDA/ARS Children's Nutrition Research Center, a multidisciplinary hub housing elite scientists conducting cutting-edge research in pediatric nutrition and metabolism. The center provides extensive resources including specialized laboratories, research accommodations, and a collaborative scientific environment.