معرفی
Overview
Sebastian Schuck is a Professor of Biochemistry and Molecular Cell Biology at Heidelberg University's Biochemistry Center (BZH). His research focuses on organelle homeostasis, particularly the endoplasmic reticulum (ER), with emphasis on ER membrane biogenesis, ER-phagy, and SHRED pathways. He leads an international team investigating how cells adapt ER structure and function under stress or disease conditions.
Education & Career
- Since 2021: Professor at Heidelberg University BZH
- 2013–2021: Independent Group Leader at Heidelberg University's Center for Molecular Biology
- 2006–2013: Postdoc with Peter Walter at UCSF
- 2001–2006: PhD and Postdoc with Kai Simons at Dresden's Max Planck Institute
- 1995–2000: Biochemistry studies at Universities of Hannover and Tübingen
Research Interests
Dr. Schuck's lab explores molecular mechanisms underlying ER homeostasis, including:
1. ER expansion during stress via lipid synthesis
2. Microautophagy-mediated ER degradation via ESCRT machinery
3. SHRED pathway regulation of proteasomal degradation of misfolded proteins
4. Links between ER stress and neurodegenerative diseases/cancer
Awards & Honors
No specific awards listed, but recognized for pioneering contributions to understanding microautophagy and ER quality control mechanisms.
Advising & Collaborations
- Advised over 20 PhD/Master's students and postdocs
- Collaborations with Carlos Bas-Orth (MPI Biochemistry), Liam Holt (NY), and others
Labs & Teams
Current lab includes 10+ members focusing on:
- Human ER morphogenesis
- Microautophagy dynamics
- SHRED pathway mechanisms
