Scott S. Terhune

Scott S. Terhune is a Professor in the Department of Microbiology & Immunology at the Medical College of Wisconsin. His research focuses on understanding human cytomegalovirus (HCMV) protein functions during infection and disease, with particular emphasis on host-pathogen interactions, neuropathogenesis, and antiviral strategies. He leads the Terhune Lab, which employs advanced proteomics, computational modeling, and cellular systems to study HCMV's impact on cellular networks. Dr. Terhune holds a PhD in Cancer Biology from Northwestern University (2000) and completed postdoctoral training at Princeton University in Proteomics/Cytomegalovirus Biology (2007).

His research interests include viral replication mechanisms, HCMV's role in chronic diseases (e.g., Alzheimer's), and the development of therapeutic approaches. The lab's work integrates experimental and computational methods, such as phospho-proteomics, MALDI-imaging, and dynamic network modeling, to dissect viral-host interactions. Recent studies highlight HCMV's effects on neuronal cells, microtubule dynamics, and CAR T-cell manufacturing optimization.

Key projects include defining how HCMV proteins manipulate cell cycle pathways, mTOR signaling, and histone modification systems. Collaborative efforts with MCW faculty and international teams expand research into multicellular tissue models and systems biology. Dr. Terhune has held leadership roles, including Past Chair of the Faculty Career Development Committee and Scientific Advisor for AHW.