معرفی
Jacek Skowronski is a Professor in the Department of Molecular Biology and Microbiology at Case Western Reserve University's School of Medicine. His research focuses on understanding HIV/SIV interactions with host cells, particularly the role of viral accessory proteins like Vpr and Vpx in evading host defenses. He leads studies on how these proteins hijack host machinery such as the E3 ubiquitin ligase complex to enable viral replication in macrophages.
Research interests include identifying cellular co-factors for HIV/SIV proteins and mechanisms of host resistance to infection. His work employs proteomics, reverse genetics, and cell biology approaches to elucidate molecular pathogenesis and potential antiviral targets. Notable projects involve characterizing the role of SAMHD1 protein and the CRL4DCAF1 ubiquitin ligase complex in HIV restriction mechanisms.
Publications highlight advancements in understanding viral-host interactions, including studies on SAMHD1 regulation by dGTP and Cyclin A2-CDK signaling. His research bridges basic virology with translational insights into antiviral strategies.
