Sarah Dean

Dr Sarah Dean is a Senior Lecturer in Healthcare/Biomedical Science at the University of the West of England (UWE Bristol), affiliated with the HAS - Applied Sciences department within the School of Applied Science. She specializes in Cellular Pathology and Cancer Biology, focusing on undergraduate and postgraduate education. Her roles include Placement Coordinator for the School of Applied Science and Module Leader for courses such as Applied Scientific Practice, Tissue and Tumour Science, and Professional Practice in Applied Science.

Her research centers on biomarkers in breast cancer, particularly Triple Negative Breast Cancer (TNBC), with emphasis on metabolic pathways, prognosis, and cellular mechanisms. She employs both in vivo and in vitro models to investigate biomarkers like BCAT isoforms, GRP78, and IGFBP-3. Collaborations include work with Dr. Claire Perks at the University of Bristol and membership in the NHS Research Ethics Committee.

Publications highlight her contributions to understanding tumorigenesis, chemoresistance, and molecular pathways in breast cancer. Key areas of exploration include EMT induction under hypoxia, PI3K/Akt signaling modulation, and the role of PTEN in TNBC progression. While no scientific awards are listed, her work bridges clinical and laboratory research, emphasizing translational outcomes.

Teaching responsibilities span cellular pathology, histology, and professional practice, with a focus on hands-on placement modules. Her research extends to acute myeloid leukemia drug resistance and low-abundance protein visualization techniques, demonstrating versatility in oncology research.