معرفی
Ramon Parsons, MD, PhD, is a Professor and Chair of Oncological Sciences at the Icahn School of Medicine at Mount Sinai, and Director of the Tisch Cancer Institute. He holds a dual appointment in the Department of Medicine, Hematology and Medical Oncology.
Education: AB in Biology from Columbia University; MD and PhD from Stony Brook University; Postdoctoral Training at Johns Hopkins University.
Research focuses on tumor suppressor pathways (e.g., PTEN/PI3K), cancer metabolism, epigenetic regulation, and chromatin dynamics. Key projects include studying PTEN’s role in breast carcinoma, metabolic reprogramming in PTEN-deficient tumors, and the therapeutic potential of PTEN-L. His lab employs mouse models, genomic approaches, and biochemical techniques to dissect cancer mechanisms.
Notable achievements include the discovery of PTEN, elucidation of PTEN’s role in cancer, and identification of PREX2 as a PTEN regulator. Recent work explores synthetic lethality in PTEN-mutant cancers and anti-tumor immunity via PTEN-Long isoforms.
- Awards: National Academy of Medicine (2017), AACR Outstanding Investigator Award (2011)
Lab Team: Includes PhD candidates and postdocs studying PTEN-L therapies, chromatin remodeling (BAF180/PBRM1), and metabolic dependencies. Collaborations span computational biology (e.g., Tiphaine Martin’s work on EMR-cancer links) and drug development (e.g., Jia Xu’s PROTAC-based PI3K inhibition).
Lab Location: Hess Center for Science and Medicine, 1470 Madison Ave, New York.
