معرفی
Sara Brown is a clinical academic dermatologist and Professor at the University of Edinburgh's Institute of Genetics and Cancer. She leads the Brown Lab, focused on molecular and genetic mechanisms of atopic eczema and related conditions. Her work integrates genomic studies, organoid models, and clinical research to explore gene-environment interactions. As a Wellcome Trust Senior Research Fellow, she collaborates with institutions like the MRC Human Genetics Unit and the University of Dundee. Current research emphasizes skin organoid modeling, transcriptomics, and translational studies to identify therapeutic targets for eczema and ichthyoses. Her lab includes postdoctoral fellows (Martina Elias, Luke Johnston) and PhD students (Ellie Earp, Silvia Shen). Funding partners include Wellcome Trust, Biomap Consortium, and Rosetrees Trust. Collaborations span dermatology, bioinformatics, and art (Edinburgh College of Art).
Research highlights include investigating filaggrin mutations' role in skin barrier dysfunction, environmental triggers, and systemic inflammation links. Notable projects include the BEEP trial (emollient prevention of eczema) and TREAT trial (comparing ciclosporin/methotrexate efficacy). Awards include Wellcome Senior Research Fellowship and ScotPEN Engagement Award. The lab's future aims address rising eczema prevalence and personalized treatment strategies.
