معرفی
Dr. Sandra M. Bell is a Lecturer and Group Leader at the Leeds Institute of Medical Research at St James's, School of Medicine, University of Leeds. Her research focuses on the functional roles of neurodevelopmental genes MCPH1 and CSMD1 in breast and ovarian cancers, with a strong emphasis on DNA repair, cell cycle regulation, and therapeutic resistance.
Her educational background includes a BSc in Biochemistry from the University of Sussex (1987) and a PhD in Colon Cancer Genetics from the University of Leeds (1992). She is also a Fellow of the Higher Education Academy (2021).
- BSc (Hons.) Biochemistry, University of Sussex, 1987
- PhD Colon Cancer Genetics, University of Leeds, 1992
- Fellow of the Higher Education Academy, 2021
Dr. Bell's research interests center on understanding how mutations and reduced expression of MCPH1 and CSMD1 contribute to cancer development, particularly through defects in mitotic regulation and genomic instability. Her group employs high-throughput siRNA screening and small molecule libraries to identify synthetic lethal interactions and potential therapeutic targets. These studies are highly relevant to overcoming drug resistance in breast and ovarian cancers.
Although specific article titles are not listed in the provided text, her research output is centered on cancer biology, functional genomics, and molecular oncology, with consistent exploration of DNA damage response pathways and tumor suppressor mechanisms. The trends in her work reflect a long-standing commitment to translational cancer research with clinical implications for prognosis and treatment.
Dr. Bell has not been mentioned as receiving any scientific awards in the provided text.
She is actively involved in student supervision and academic leadership. She has supervised numerous PhD and MSc students to completion, both as primary supervisor and co-supervisor. She serves as a Personal Tutor for MBChB students and Postgraduate Research Tutor for MD/PhD students. Additionally, she is the Programme Lead for the International PhD Academy: Medical Research at St James’s University Hospital, playing a key role in graduate training and international research collaboration.
Dr. Bell leads her own research group within the Breast Cancer Research Group at the Leeds Institute of Medical Research. She was a founding member of the BioScreening Technology Group (BSTG), dedicated to high-throughput, high-content siRNA screening. Her lab utilizes both in vitro and in vivo models to study gene function and therapeutic resistance, contributing to a broader team-based effort in cancer biology at the university.
