معرفی
Sabrina Arena is an Associate Professor at the University of Torino's Department of Oncology, affiliated with the Candiolo Cancer Institute (IRCCS-FPO). Her research focuses on overcoming therapeutic resistance in colorectal, prostate, and ovarian cancers by exploiting vulnerabilities in DNA repair pathways and metabolic processes. She leads the Translational Cancer Genetics Laboratory, developing preclinical models (e.g., organoids, patient-derived xenografts) to guide precision medicine strategies.
Her work emphasizes synthetic lethality targeting in DNA damage response (DDR) pathways and vitamin C's role in enhancing therapy efficacy. Key contributions include identifying EGFR extracellular domain mutations driving resistance to anti-EGFR therapies and validating drug combinations to counteract acquired resistance. She collaborates with institutions like the University of Torino and IRCCS-FPO, contributing to clinical trials and translational research.
Research highlights include:
- Discovery of EGFR ECD mutations and novel therapeutic strategies against them.
- Identification of DDR pathway vulnerabilities for targeted therapies.
- Development of preclinical models mirroring clinical tumor heterogeneity.
Her lab's future goals involve expanding synthetic lethal targeting and metabolic interventions to improve long-term treatment outcomes.
