معرفی
Professor Ian Hickson is affiliated with Newcastle University, where he leads research in cancer biology and molecular oncology. His work focuses on DNA repair mechanisms, synthetic lethality, and androgen receptor signaling in prostate and ovarian cancers.
Research Interests:
- DNA repair pathways in cancer cells
- Synthetic lethality for targeted therapies
- Androgen receptor signaling and mutations
- Development of protein-protein interaction inhibitors
- Cancer metabolism vulnerabilities
- Chemoresistance mechanisms
Recent Publications: His 15 most recent works (2014–2025) highlight advancements in prostate cancer therapeutics, DNA repair enzyme inhibition, metabolic dependencies in medulloblastoma, and synthetic lethality strategies. Key targets include AR variants, DNA-PK, FEN1, and USP45.
Collaborations: His projects involve multidisciplinary teams, including co-authors like Dr. Natalie Tatum, Dr. Beth Adamson, and Dr. Nicholas Brittain, with applications in clinical-stage drug development and preclinical models.