Sabine Windhorst

Prof. Sabine Windhorst is a Professor at the Institute of Biochemistry and Signal Transduction within the Faculty of Medicine at the University Medical Center Hamburg-Eppendorf (UKE). She leads a scientific working group focusing on cellular mechanisms in cancer biology, cytoskeleton dynamics, and signal transduction. Her research integrates molecular biology, structural biology, and oncology to explore how cytoskeletal proteins and signaling pathways influence cancer progression and metastasis.

Key research interests include the role of actin-binding proteins, exosome biology, and microtubule regulation in tumor metastasis. Her work spans disciplines such as immunology (e.g., tumor-immune interactions) and microbiology (e.g., bacterial pathogenesis mechanisms). Recent studies highlight contributions to understanding exosome-mediated cargo transport, immunosuppressive cytokine secretion in pancreatic cancer, and structural biology of pathogenic proteins.

Publications from 2025 emphasize advancements in exosome cargo loading, tumor microenvironment interactions, and therapeutic antibody development targeting actin dynamics. Her work often bridges basic science with translational applications, such as drug discovery and novel therapeutic strategies.

Prof. Windhorst collaborates with interdisciplinary teams across cancer research, structural biology, and microbiology. Her lab’s research has implications for improving cancer diagnosis, understanding metastatic mechanisms, and developing targeted therapies.