معرفی
Professor S. Murty Srinivasula is a distinguished molecular biologist currently serving as Professor at the Indian Institute of Science Education and Research Thiruvananthapuram (IISER TVM), where he also holds the position of Deputy Director (June 2022-May 2025). His academic journey includes significant roles as Officiating Director (Feb-March 2019), Professor in-charge (Admin) (May 2019–May 2022), and Registrar (May 2019-May 2021) at IISER TVM, along with chairing the School of Biology (2012–2014) and serving as Dean of Student Affairs (2013–2015).
Professor Srinivasula received his Ph.D. in Biochemistry and Molecular Biology from Banaras Hindu University, Varanasi, following M.Sc. and B.Sc. degrees in Biochemistry and Chemistry/Mathematics/Physics respectively from Andhra University, Waltair. Prior to joining IISER TVM, he had an extensive research career in the United States, serving as Principal Investigator at the National Cancer Institute, NIH (2003-12), and holding research positions at Thomas Jefferson University and Albert Einstein Medical Center.
His research focuses on the intricate mechanisms of cell death pathways, particularly apoptosis and autophagy, with emphasis on ubiquitination processes, mitochondrial dynamics, and innate immune responses. Professor Srinivasula's laboratory has made significant contributions to understanding E3 ubiquitin ligases (particularly RFFL and CARP family proteins), their roles in regulating mitochondrial morphology, protein quality control, and cellular stress responses. His work bridges fundamental molecular mechanisms with potential therapeutic applications in cancer and neurodegenerative diseases.
Analysis of his recent publications (2023-2025) reveals a continued focus on ubiquitin-mediated protein regulation, with particular emphasis on RFFL's role in mitochondrial dynamics, CARP proteins in regulating protein aggregation, and connections between innate immune signaling and cellular quality control mechanisms. His research increasingly incorporates advanced imaging techniques and nanotechnology applications, reflecting an interdisciplinary approach to complex biological questions.
Professor Srinivasula has held numerous leadership positions within IISER TVM, serving on the Board of Governors, Finance Committee, Building and Works Committee, Senate, and Institutional Biosafety Committee. He has also chaired the Institutional Animal Ethics Committee and Institutional Standard Purchase Committee, demonstrating his commitment to institutional governance and research ethics.
His laboratory maintains active collaborations with researchers across India and internationally, with recent work showing strong connections between basic mechanisms of protein regulation and potential applications in cancer therapy and infectious disease. The lab has developed expertise in advanced microscopy techniques, including home-built simultaneous multiple-level magnification selective plane illumination microscopy systems for studying dynamic cellular processes.
