معرفی
Ruzbeh Mosadeghi, MD, PhD serves as Assistant Professor of Medicine at the University of California, San Francisco (UCSF) School of Medicine. His academic appointments reflect his dual training as a physician-scientist with expertise spanning basic molecular research and clinical gastroenterology.
Dr. Mosadeghi completed his educational training through a rigorous physician-scientist pathway: PhD in Biology from California Institute of Technology (2015), MD from Keck School of Medicine of USC (2017), Internal Medicine Residency at Columbia University Medical Center (2019), and Gastroenterology Fellowship at UCSF (2023).
His research focuses on fundamental mechanisms of protein degradation, particularly the ubiquitin-proteasome system and COP9 signalosome function. His work bridges molecular biochemistry with cellular signaling pathways, investigating how protein modification systems regulate cellular processes. Analysis of his publication timeline reveals an evolution from early work on flavin-containing monooxygenases (2007) to sophisticated structural and kinetic analyses of the ubiquitin system (2012-2016), demonstrating increasing specialization in protein regulation mechanisms.
His scholarly contributions, though limited in number (4 publications between 2007-2016), have generated substantial impact with citations ranging from 9 to 78 per paper, indicating significance within specialized research communities. Network analysis of his publications reveals connections to key concepts including Cullin Proteins, Ubiquitins, Peptide Hydrolases, and Multienzyme Complexes.
Dr. Mosadeghi collaborates with prominent researchers in the field, including Deshaies RJ, Rothenberg EV, and Aebersold R, suggesting integration within established research networks focused on protein regulation and cellular signaling pathways.
