معرفی
David Lonard is a Professor in the Department of Molecular and Cellular Biology at Baylor College of Medicine and a member of the Dan L Duncan Comprehensive Cancer Center. He holds a Ph.D. and B.S. from Texas A&M University. His laboratory investigates molecular mechanisms linking proteasome-mediated protein degradation to nuclear receptor gene expression, with a focus on developing small-molecule inhibitors targeting steroid receptor coactivators (SRCs) for cancer, metabolic disorders, and reproductive health.
Research Interests: Dr. Lonard's work spans nuclear receptor signaling, ubiquitin-proteasome dynamics, and coactivator pharmacology. Key areas include protein degradation pathways, therapeutic targeting of SRCs, and hormonal regulation of gene expression.
Scientific Contributions: His publications reveal consistent themes in oncogenic coactivator regulation, stress response mechanisms, and computational modeling of cellular processes. Recent work emphasizes SRC-3's role in cancer progression and drug resistance.
Grants & Funding: He leads NIH-funded projects, including the development of SRC-2 antagonists for male contraception. His lab employs high-throughput screening to identify novel coactivator modulators.
