معرفی
Ruli Gao serves as Assistant Professor in the Department of Biochemistry and Molecular Genetics at Northwestern University's Feinberg School of Medicine, leading a research laboratory focused on cancer evolutionary models and cell fate transition trajectories during cancer progression and therapeutic responses.
Dr. Gao holds an MS (2013) and PhD (2014) from the University of Florida. Their research program develops novel long-read single cell sequencing technologies and computational tools, with key contributions including the punctuated copy number evolution model (Nature Genetics, 2016), bi-mode chemoresistance evolution model (Cell, 2018), COPYKAT algorithm (Nature Biotechnology, 2021), and scNanoGPS technology (Nature Communications, 2023).
The laboratory's current work integrates same-cell multi-omics to co-project tumor cell genetic evolutionary lineages, cell fate transition trajectories, and adaptive immunological remodeling during cancer metastasis and recurrence. Recent publications demonstrate strong activity across cancer genomics, immunology, and cardiovascular applications, with particular emphasis on same-cell genotype-phenotype analysis in human tumors.
Dr. Gao serves as Scientific Advisory Board Member for the Pathology Core Facility at Northwestern University Feinberg School of Medicine (2024-present) and has developed multiple influential computational tools including COPYKAT for calculating single cell copy number clonality. The laboratory actively expands applications of their novel methodologies to diverse human disease models including heart aging, heart failure, and transplantation rejection.
The Gao laboratory maintains active research programs in tumor evolution modeling, single-cell technology development, and translational applications across oncology and cardiovascular medicine, with recent work featured in Nature Genetics, Journal of Clinical Investigation, and Nature Communications.
