معرفی
Weiguo Cui serves as Professor of Pathology at Northwestern University's Feinberg School of Medicine, conducting research through the Center for Human Immunobiology and Robert H. Lurie Comprehensive Cancer Center. His work focuses on T cell biology in cancer immunology, viral pathogenesis, and autoimmune disorders.
His research examines molecular regulators of CD8+ T cell fate, including transcription factors (SATB1, KLF2, BATF) and metabolic pathways (mitochondrial respiration, CD36 signaling). Key interests encompass T cell exhaustion mechanisms, stem-like memory formation, and metabolic reprogramming during chronic infections. His lab employs single-cell RNA sequencing, clonal lineage tracing, and spatial transcriptomics to dissect heterogeneity in immune responses.
Analysis of recent publications reveals a cohesive research trajectory investigating how transcriptional and metabolic networks govern T cell differentiation. His 2024-2025 work demonstrates how factors like ID3 define stem-like progenitors, while PKM2-mtROS pathways link metabolism to immune function. This integrative approach bridges basic immunology with therapeutic applications in cancer and chronic infections.
Dr. Cui maintains active collaborations through Northwestern's immunology centers, focusing on translating mechanistic insights into immunotherapeutic strategies. His research program emphasizes the therapeutic potential of modulating T cell exhaustion pathways and metabolic checkpoints to enhance anti-tumor immunity.
