Roy Wollman

Roy Wollman is a Professor at the University of California, Los Angeles (UCLA) in both the Department of Integrative Biology and Physiology and the Department of Chemistry and Biochemistry within the College of Letters and Science. His work bridges experimental and computational approaches to study dynamic signaling networks and their impact on cellular decisions.

• Research Focus: Computational and systems biology of signaling pathways
• Key Techniques: Single-cell analysis, spatial transcriptomics, quantitative modeling
• Major Themes: Information transmission in biochemical networks, cellular decision-making, epigenetic regulation

Recent work has emphasized spatial transcriptomics mapping of brain regions, wound response signaling, and multi-scale analysis from cell biology to physiology. His lab has developed computational tools like scPNMF for gene selection and JSTA for cell segmentation and annotation. Key findings include mechanisms of TNF-induced cell death tradeoffs and laminin scarring effects in stem cell function.

Roy Wollman has received continuous NIH funding since 2009, including grants for studying NFκB dynamics (R01GM117134), corneal wound signaling (R01EY024960), and single-cell technologies for traumatic brain injury (R01NS117148). His research combines high-throughput microscopy with computational modeling to understand how cells process dynamic signals.