Jun Hee H. Lee

Jun Hee H. Lee is a Professor of Molecular and Integrative Physiology and Research Professor at the Institute of Gerontology within the University of Michigan's Medical School. He serves as Associate Director of Academic Programs in Molecular and Integrative Physiology. His research focuses on stress, aging, and metabolism, particularly exploring stress adaptation mechanisms that enhance cellular resilience and longevity. Lee's work integrates molecular biology, genomics, and technology development to understand age-related diseases and metabolic disorders.

Research affiliations include the Center for Computational Medicine and Bioinformatics, Caswell Diabetes Institute, Rogel Cancer Center, and others. Key areas of investigation include Sestrin signaling, autophagy dysfunction in diseases like NAFLD, and single-cell spatial transcriptomics. Recent breakthroughs include the Seq-Scope technology for spatial gene expression visualization, which earned him the 2024 Hanseong Science Award in Life Sciences.

• Key Technologies: Spatial transcriptomics, single-cell analysis
• Clinical Focus: Metabolic disorders, cancer, cardiovascular health
• Interdisciplinary Collaborations: Bioinformatics, computational medicine, systems biology

Lee's lab actively develops tools to study cellular stress responses at unprecedented resolution, with applications in drug discovery and precision medicine. His mentorship supports students and researchers in translating molecular insights into clinical solutions.