Matthew K. Iyer

Matthew K. Iyer, MD, PhD, is a Clinical Assistant Professor of Surgery and Pathology at the University of Michigan Medical School. He cares for patients at the University of Michigan Hospital and the Ann Arbor VA Healthcare System. His research focuses on computational biology, bioinformatics, and data science to improve cancer care, particularly using high-throughput molecular data like RNA sequencing. He is affiliated with the Rogel Cancer Center and the Center for Computational Medicine and Bioinformatics.

• Education:
  • BS Electrical and Computer Engineering, University of Colorado Boulder (2003)
  • BA Music, University of Colorado Boulder (2003)
  • MS Electrical Engineering, University of Colorado Boulder (2006)
  • PhD, University of Michigan–Ann Arbor (2016)
  • MD, University of Michigan Medical School (2016)
  • Residency in General Surgery, Weill Cornell Medicine (2021)
  • Fellowships in Complex General Surgical Oncology and HPB Surgery, Duke University Health System (2023)

His research emphasizes developing biofluid tests for cancer detection, investigating tumor biology via spatial transcriptomics and single-cell RNA-Seq, and curating large RNA-Seq datasets for cancer research. Recent work includes spatial analysis of pancreatic neoplasms and microbiome studies in pancreatic disease.

Publications span spatial transcriptomics of pancreatic tumors, mouse models for liposarcoma, and microbiome assessments. His work bridges clinical care and computational methods to advance oncology.