Qing Nie

Qing Nie is a Distinguished Professor of Mathematics and Developmental & Cell Biology at the University of California, Irvine (UCI), with affiliation to the Biomedical Engineering Department. He directs the NSF-Simons Center for Multiscale Cell Fate Research, focusing on computational systems biology, cell fate dynamics, and single-cell RNA-seq analysis. His work integrates mathematical modeling, computational tools, and experimental data to study developmental processes, tissue regeneration, and disease mechanisms.

• Affiliations: UCI Departments of Mathematics, Developmental & Cell Biology, and Biomedical Engineering
• Key Expertise: Multiscale biological systems, spatial transcriptomics, cell-cell communication analysis, and computational methods for omics data

Research interests span mathematical modeling of cellular processes, development of analytical tools for single-cell and spatial transcriptomics, and understanding how signaling pathways regulate cell fate decisions. Notable contributions include CellChat (a systematic analysis framework for cell-cell communication) and spatial transition tensor methods for analyzing spatial transcriptomics data. His work bridges computational and experimental biology, with applications in cancer, wound healing, and developmental biology.

Recent publications highlight advancements in spatial transcriptomics analysis, tumor microenvironment modeling, and evolutionary developmental biology. Collaborations with experimental labs (e.g., M. Plikus, Ricardo Mallarino) underscore his translational approach. Awards include recognition as a top scholar in transcriptomics technologies (ScholarGPS).