معرفی
Rick Dobrowsky is a Professor and Director of the Graduate Program in Neuroscience at the University of Kansas School of Pharmacy, Department of Pharmacology & Toxicology. His research focuses on diabetic peripheral neuropathy, molecular chaperones, and sphingolipid signaling in neuronal degeneration.
- Location: Malott Hall, Room 5064, Lawrence, KS
- Contact: dobrowsky@ku.edu | 785-864-3531
Research Overview: The Dobrowsky Lab investigates how hyperglycemia alters neurotrophin signaling and mitochondrial proteomes in diabetic neuropathy. Key projects include:
- Hyperglycemia and IGF-1 signaling effects on superoxide generation
- Neuregulinism's role in segmental demyelination
- Development of HSP90 inhibitors for neuroprotection
Publications (15 Most Recent):
- 2025: PERK signaling and Cemdomespib therapy in Charcot-Marie-Tooth disease
- 2024: Demyelination progression in R75W-Connexin 32 models
- 2023: Biphenyl amides as HSP90/HSP70 modulators
- 2022: Cyclohexyl noviomimetics and mitochondrial function
- 2021: HSP70/thioredoxin interactions in diabetic neurons
- 2020: HSP90 inhibition and c-Jun proteasomal clearance
- 2019: Mitochondrial superoxide reduction with KU-596
- 2018: HSP70 targeting for demyelination
- 2016: Cemdomespib and neurotrophin receptor dynamics
- 2015: Molecular chaperones and mitochondrial bioenergetics
- 2014: KU-32 and heat shock protein mechanisms
- 2013: Neuregulin-1 isoforms in diabetic neuropathy
- 2012: C-terminal HSP90 inhibitors in sensory neuron protection
- 2011: Mitochondrial proteome changes in diabetes
- 2010: P35/CDK5 in beta-amyloid toxicity
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