معرفی
Rick T. Dobrowsky is a Professor in the Department of Pharmacology & Toxicology at the University of Kansas School of Pharmacy. He also serves as Director of the Graduate Program in Neuroscience. His research focuses on diabetic neuropathy and molecular chaperones, exploring how hyperglycemia impacts neurotrophin signaling and mitochondrial function in peripheral nerves.
Education:
- Ph.D. in Pharmacology, North Carolina State University (1990)
- Postdoctoral Training at Duke University Medical Center (1995)
Research Interests:
His work examines molecular mechanisms underlying diabetic neuropathy, including neuregulin signaling, mitochondrial proteome changes, and the role of molecular chaperones like Hsp70 and Hsp90. Current projects investigate how hyperglycemia alters IGF-1 signaling and neuregulinism to drive neuropathic damage.
Publications:
Recent work highlights therapies targeting molecular chaperones to treat diabetic neuropathy and Charcot-Marie-Tooth disease, including cemdomespib and noviomimetic compounds. Key findings include improved mitochondrial function and reduced demyelination in animal models.
Advising & Grants:
He has advised students like Sukhmanjit Kaur and Yssa Rodriguez. His lab collaborates on NIH-funded projects exploring mitochondrial dysfunction in diabetes and molecular chaperone-based therapies.
Labs:
Director of the Dobrowsky Lab, which studies signaling pathways in nerve degeneration and develops novel therapeutic approaches for peripheral neuropathies.
