معرفی
Richard M. Higashi, PhD, is a Professor in the Department of Toxicology and Cancer Biology at the University of Kentucky. He holds affiliations with the Center for Environmental and Systems Biochemistry, focusing on metabolic pathways in cancer. His research emphasizes stable isotope-resolved metabolomics (SIRM) to study tumor metabolism, drug responses, and the tumor microenvironment. Key areas include metabolic reprogramming in breast and lung cancers, immune cell metabolism, and developing preclinical models for personalized medicine.
Research interests span cancer metabolism, immunometabolism, and novel therapeutic strategies targeting metabolic vulnerabilities. Notable contributions include organoid-based platforms for patient-specific analyses and identifying metabolic biomarkers for treatment efficacy. His work integrates advanced mass spectrometry and metabolomics techniques to dissect cell-type specific metabolic profiles in tumors and immune cells.
Publications highlight metabolic heterogeneity in NSCLC, mitochondrial dysfunction in radiation resistance, and CD8+ T cell metabolic adaptations enhancing antitumor activity. His team explores selenium-based therapies and exosomal biomarkers for cancer diagnosis. Collaborations focus on translating metabolomics data into clinical applications for precision oncology.
Advising and grants are not explicitly detailed in the provided text, but his lab likely engages in multidisciplinary projects at the interface of basic metabolism and clinical oncology. The Center for Environmental and Systems Biochemistry supports systems-level approaches to environmental toxin impacts and cancer biology.
