Raphaël Carapito

Raphaël Carapito serves as Professor and Scientific Lead of the GENOMAX platform at the University of Strasbourg, specializing in genomics, transcriptomics, and multiomics applications for autoimmunity, inflammation, immune deficiencies, and transplantation research. The GENOMAX facility operates as both a research hub and fee-for-service provider with ThermoFisher Scientific since 2013.

His research focuses on developing NGS-based methodologies including HLA domain analysis, exome/RNAseq pipelines, disease gene identification, and multi-omics approaches for complex immunological traits. Recent work integrates viral/cancer genome sequencing with deep mutational analysis. The GENOMAX team maintains state-of-the-art infrastructure including Illumina NextSeq systems, Ion Torrent platforms, and bioinformatics clusters for comprehensive genomic analysis.

Analysis of 2024-2025 publications reveals dominant themes in immunogenetics, with significant contributions to understanding STING pathway disorders, complement deficiencies, leukocyte adhesion defects, and cancer-immunity interactions. Methodologically, the work spans mouse models, clinical case studies, multi-omics integration, and machine learning applications for precision diagnostics.

Carapito advises Master's student Jeremie Carabin and secures substantial funding from Cancéropole Grand-Est, FEDER Interreg V, French Ministry of Higher Education, Investissements d’avenir, and private partners including Novartis and WuxiNextCode. The GENOMAX platform collaborates extensively with clinical departments (Rheumatology, Immunology, Hematology), national research units (INSERM, EFS), and international institutions including Boston Children's Hospital and University of Freiburg.

The facility provides comprehensive genomic services including whole-genome/exome sequencing, RNA-seq, ChIP-seq, and metagenomics through advanced equipment like NextSeq2000, Ion Proton, and automated library preparation systems. Current projects emphasize translational applications in transplantation immunology, cancer genomics, and rare immunodeficiency disorders.