معرفی
Randy Mrsny is a Professor in the Department of Life Sciences at the University of Bath, where he leads the Mrsny Laboratory within the Centre for Therapeutic Innovation. His work bridges academic research and industrial pharmaceutical development, with a strong focus on epithelial biology and advanced drug delivery systems.
His research interests center on epithelial cell structure and function in health and disease, particularly:
- Identification of epithelial-secreted molecules regulating immune cell transmigration (neutrophils, eosinophils)
- Mechanisms of lymphocyte activation control by epithelial cells
- Role of tight junctions in epithelial oncogenesis and dynamic regulation for drug delivery
- Exploitation of bacterial toxin transcytosis pathways for delivering biotherapeutics (proteins, peptides, siRNA)
His recent publications reflect a strong trend in developing innovative in vitro models for drug delivery, particularly focusing on subcutaneous and intramuscular injection sites using biomimetic hydrogels. His work integrates pharmaceutical sciences, cell biology, and biomaterials to improve the delivery and efficacy of biopharmaceuticals. Key themes include tight junction modulation, toxin-based delivery systems, and formulation science for sustained release.
Randy Mrsny has led multiple externally funded projects from agencies such as the MRC and BBSRC, including initiatives on peptide synthesis platforms, light sheet microscopy, and enhanced oral delivery of biopharmaceuticals. He has also participated in Knowledge Transfer Partnerships with industry, demonstrating strong translational impact.
He has supervised 11 research students and early-career researchers. His laboratory collaborates extensively with pharmaceutical companies and international agencies, and he serves as an advisor and reviewer for multiple organizations. The Mrsny Lab contributes to UN Sustainable Development Goals related to good health and well-being through its focus on therapeutic innovation.
