Rajasekaran Mahalingam

Dr. Rajasekaran Mahalingam is an Assistant Professor in the Department of Symptom Research at The University of Texas MD Anderson Cancer Center. He holds a Ph.D. in structural biology and bioinformatics from National Tsing Hua University, Taiwan. His research focuses on transcriptomics analysis and gene expression changes associated with diseases, particularly chemotherapy-induced cognitive impairment and neuropathy. Utilizing bioinformatics and RNA sequencing techniques, he investigates cellular mechanisms underlying neurotoxicity and identifies potential drug targets.

Key research projects include:

• Discovery of gene expression alterations in neuronal and non-neuronal cells exposed to doxorubicin
• Identification of pathways combating cisplatin-induced neurotoxicity in mouse models
• Analysis of myeloid cell signatures in neuropathic pain using RNA sequencing
• Exploration of metabolic shifts in chemotherapy-treated brain tissues and dorsal root ganglia

His work bridges structural biology and translational research, aiming to mitigate chemotherapy side effects through molecular-level insights.