Rajan Jain

Rajan Jain, MD, is the William Wikoff Smith Associate Professor in Cardiovascular Research at the University of Pennsylvania, affiliated with the Perelman School of Medicine and the Department of Medicine. With a dual background in cardiology and developmental biology, his lab investigates how 3D genome organization governs cardiac cell identity and disease.

• Key Research Areas:
  • 3D chromatin spatial positioning in cardiomyocytes
  • Pathogenic LMNA variants in laminopathies
  • BET protein regulation of genome folding (BRD4-GATA4 axis)
  • Cellular plasticity mechanisms in transdifferentiation
• Collaborations:
  • Joyce Lab (3D Genomics)
  • Lakadamyali Lab (Imaging)
  • Raj Lab (Cell Plasticity)
  • 4D Nucleome Consortium
• Scientific Awards:
  • NIH New Innovator Award (DP2HL147123)
  • NHLBI R01 Grant (HL139783)
  • Transformative Research Award (R01GM137425)

The lab employs genome-wide CRISPR screens, mouse/human iPSC models, and high-resolution imaging to decode spatial genome rules. Their work has redefined understanding of lamin-associated domains in cardiac development and BRD4's role in cohesin stability.