معرفی
Robert Babak Faryabi is an Associate Professor at the University of Pennsylvania's Perelman School of Medicine, affiliated with multiple institutes including the Abramson Family Cancer Research Institute, Penn Epigenetics Institute, and Institute for Biomedical Informatics. His research focuses on epigenetic mechanisms in cancer, particularly genome mis-folding, transcriptional addiction, and drug resistance in lymphomas and breast cancers.
- Key roles: Associate Professor of Pathology and Laboratory Medicine, Core Faculty Member at Penn Epigenetics Institute, Senior Fellow at Institute for Biomedical Informatics
- Education: BSc/MSc in Electrical and Computer Engineering (Sharif University), PhD in Computational Biology (Texas A&M)
His lab combines genomics, super-resolution imaging, and machine learning to decode oncogenic chromatin organization and develop tools like TooManyCells for single-cell analysis. Recent work includes spatial promoter-enhancer hubs in cancer and epigenetic repositioning in therapy resistance.
Software contributions include the TooManyCells pipeline for single-cell data analysis and visualization. The lab also collaborates with the Center for Personalized Diagnostics to translate findings into clinical applications.
Research areas include:
- Epigenetic vulnerabilities in cancer
- Single-cell heterogeneity analysis
- 3D genome folding in oncogenesis
- Computational methods for spatial proteomics
