Qizhen Shi

Dr. Qizhen Shi is a Professor in the Department of Pediatrics at the Medical College of Wisconsin and a Senior Investigator at the Blood Research Institute, Versiti Wisconsin. He holds memberships in the Center for Immunology and Center for Microbiome Research, emphasizing interdisciplinary collaboration in hematology and immunology.

His research focuses on:

• Platelet-targeted gene therapy for hemophilia A/B, developing strategies to induce immune tolerance and overcome inhibitory antibodies
• Factor VIII immunology, investigating T follicular helper cells, CXCL13 signaling, and mechanisms of inhibitor formation
• Von Willebrand factor biology and its role in platelet adhesion, hemostasis, and thrombus stabilization
• Hematopoietic stem cell engineering for sustained coagulation factor delivery and phenotypic correction

Dr. Shi's 86 publications demonstrate consistent productivity, with recent work (2022-2025) advancing siRNA/nanoparticle therapies, novel conditioning regimens, and mechanistic insights into platelet clearance and immune regulation. His articles frequently appear in high-impact journals like Blood and Nature Communications.

He leads research at Versiti's Blood Research Institute and mentors junior faculty, though specific student advisees and lab details are not provided in the source material.