Marie-T. Hopp

Marie-T. Hopp is a researcher affiliated with the Institute of Physical Chemistry at Friedrich Schiller University Jena, Germany, and collaborates with the Medical Faculty's Center for Sepsis Control and Care. Her work focuses on the molecular interactions between coagulation factors and heme in hemolytic conditions.

Research Interests:

• Structure-function analysis of coagulation factor VIII
• Pathophysiological effects of heme-binding in hemolysis
• Thrombosis and hemostasis in hemophilia A
• Biophysical characterization of protein-heme complexes
• Cryo-EM and molecular dynamics simulations

Articles (2024): Her recent study In-depth structure-function profiling of the complex formation between clotting factor VIII and heme demonstrates heme's inhibitory effect on FVIII cofactor activity, with implications for hemophilia A treatment.