Sriram Krishnaswamy

Sriram Krishnaswamy, PhD, is an Investigator at the Children's Hospital of Philadelphia (CHOP) Research Institute, where he leads an independent research laboratory focused on the molecular mechanisms of blood coagulation. He is affiliated with the Department of Pediatrics, Division of Hematology, and the Cell Biology Research Affinity Group at CHOP.

His research investigates how coagulation proteins interact with each other and with cell membranes to produce a regulated clotting response following vascular injury, or an unregulated response in conditions such as thrombosis or bleeding disorders. The Krishnaswamy Laboratory employs a multidisciplinary approach combining biophysical methods, mutagenesis, functional assays, and advanced structural techniques including X-ray crystallography, small-angle X-ray scattering, high-resolution cryo-electron microscopy, and hydrogen-deuterium exchange mass spectrometry.

The lab’s work aims to uncover fundamental mechanisms of proteolytic activation in coagulation, enzyme-cofactor-membrane complex assembly, substrate recognition, and the structural basis of catalytic enhancement. These mechanistic insights are intended to inform the development of novel therapeutic strategies for modulating coagulation in disease.

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• Scientific Awards: No awards mentioned.

Dr. Krishnaswamy mentors research trainees as part of his laboratory leadership, though specific students are not named. There is no mention of grants in the provided text. He leads the Krishnaswamy Laboratory at the Leonard and Madlyn Abramson Pediatric Research Center, where his team conducts cutting-edge research in hemostasis and thrombosis.