Pål Stenmark

Pål Stenmark is a Professor of Biochemistry at the Department of Biochemistry and Biophysics, Stockholm University. His research focuses on botulinum neurotoxins and structure-based drug design, particularly targeting enzymes in nucleotide metabolism for cancer therapy.

• Research Interests
  • Elucidating the molecular mechanisms of botulinum neurotoxins using X-ray crystallography and cryo-EM.
  • Developing novel cancer drugs through structural insights into proteins like MTH1 and OGG1, which are critical for managing oxidative DNA damage.
  • Applying interdisciplinary collaborations to refine inhibitors for therapeutic applications.
• Scientific Awards
  • Awarded a grant from the Swedish Brain Foundation (Hjärnfonden) in 2023 for research on ALS, Epilepsy, and Alzheimer's.
• Students and Collaborators
  • Supervises a team including PhD students and postdocs such as Chloe Leveque, Maria Nowakowska, and Ellen Walse.
  • Laboratory members engage in projects spanning protein structure, neurotoxin interactions, and nanobody tools for synaptic imaging.
• Publications
  • His recent work explores trends in botulinum toxin engineering, OGG1 activation, and endolysin structures for food safety applications.