معرفی
Filip Van Petegem is a Professor in the Department of Biochemistry & Molecular Biology at the University of British Columbia's Faculty of Medicine. His research focuses on ion channels, particularly calcium and sodium channels, using advanced techniques like Cryo-EM, X-ray crystallography, and electrophysiology to understand their role in cardiac arrhythmias, epilepsy, and other channelopathies.
- Education: Licensee (1998) and PhD (2002) in Biochemistry from Ghent University
- Awards: CIHR New Investigator, MSFHR Career Investigator
His work investigates how auxiliary proteins, post-translational modifications, and small molecules alter ion channel behavior, with current projects centering on L-type calcium channel-RyR communication and calcium-dependent memory mechanisms. Recent structural studies of ryanodine receptors with diamide insecticides and statins provide insights into drug binding and resistance mechanisms. His lab has also developed high-throughput systems for discovering novel ion channel modulators and characterized disease-associated mutations in Cav1.2 and RyR2 channels.
Scientific awards include
- CIHR New Investigator
- MSFHR Career Investigator
He actively collaborates on ion channel research networks and has developed diagnostic tools using nanobodies for multi-pass membrane proteins. His team's structural characterization of ABCA4 nucleotide-binding domains in Stargardt disease and exploration of monoclonal antibodies for aquaculture/poultry pathogens demonstrate biomedical and agricultural applications of his work.
