معرفی
Philip Askenase is Professor of Medicine in the Department of Internal Medicine at Yale School of Medicine, with a focus on Immunology. He is affiliated with the Cancer Immunology program, the Center for Brain & Mind Health, and the Center for RNA Science and Medicine at Yale.
Research Interests:
- Immunochemistry and cellular immunity
- B-1 B cell functions in T cell immunity
- Regulatory T cells and antigen-specific suppression
- Exosome-mediated transfer of miRNA (e.g., miRNA-150) in immune regulation
- Applications in allergy, autoimmunity, cancer, and spinal cord injury
- Development of exosome-based diagnostics (liquid biopsy) and therapeutics
His recent publications highlight the role of extracellular vesicles in psychiatric conditions, pandemic prevention through chromatin vaccines, and systems vaccinology in HIV. These works reveal a strong trend toward interdisciplinary research bridging immunology, neuroscience, and regenerative medicine, with a focus on novel therapeutic delivery systems using exosomes.
Scientific Awards:
- Legends of Allergy and Immunology (Wiley Online Library, 2023)
Dr. Askenase has mentored numerous researchers and collaborators, though specific student names are not listed. His work has been supported by extensive research funding, particularly in immunology and exosome biology. He has contributed to major advances in understanding exosome carrier effects and their resistance to phagolysosomal digestion, which enhances targeted delivery.
He is a key member of collaborative teams including the Yale Center for RNA Science and Medicine and the Cancer Immunology initiative. His lab investigates how exosomes from mesenchymal stem cells promote functional recovery in spinal cord injury through modulation of macrophage phenotypes and microvascular stabilization.
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