Mark Ansel

Mark Ansel is a Professor in the Department of Microbiology & Immunology at the University of California, San Francisco (UCSF). His research focuses on molecular mechanisms governing lymphocyte development, differentiation, and immune function, particularly in the context of allergies, asthma, and autoimmune diseases. He investigates how microRNAs (miRNAs), transcription factors, and epigenetic regulation collectively shape gene expression programs in immune cells.

• Research Area: RNA regulation in adaptive immunity
• Key Techniques: Mouse genetics, high-dimensional molecular analysis, CRISPR screens

The Ansel lab emphasizes miRNA homeostasis, extracellular RNA communication, and post-transcriptional control of T and B cell responses. His work has implications for understanding and treating immune pathologies such as asthma, chronic inflammation, and viral infections like COVID-19.

Recent publications highlight his team's discoveries on miRNA clusters (e.g., miR-15/16, miR-23-27-24) in regulating T cell survival, differentiation, and cytokine production. Collaborative projects span allergy research, RNA-binding proteins (RBPs), and multi-omics analysis of immune trajectories in diseases.