معرفی
Professor Persephone Borrow is a Professor of Viral Immunology in the Nuffield Department of Medicine (NDM) at the University of Oxford, with primary affiliation at the Jenner Institute. Her research addresses critical gaps in HIV vaccine development through detailed analysis of early host immune responses to infection.
Her work spans three core projects: (1) Optimizing CD4 T follicular helper cell responses and transiently modulating regulatory constraints to elicit broadly neutralizing antibodies against HIV; (2) Investigating innate immune mechanisms (type 1 interferons, natural killer cells) in acute HIV infection to identify novel vaccine enhancement strategies; and (3) Defining correlates of viral control through analysis of CD8+ T cell responses, viral escape mutations, and immunopeptidomic approaches for novel epitope discovery. This research targets fundamental roadblocks in HIV vaccine design.
Analysis of her 2023-2025 publications reveals a multidisciplinary focus on immunological mechanisms across HIV, SARS-CoV-2, cytomegalovirus, and cancer. Key trends include T cell biology in viral control, innate immunity modulation, MHC-restricted responses, and therapeutic antibody development, demonstrating strong translational links between basic immunology and clinical applications.
No scientific awards were specified in the source material.
Professor Borrow leads an independent research group within the Jenner Institute conducting laboratory and translational studies on HIV immunopathogenesis. Her team collaborates extensively across NDM, leveraging Oxford's vaccinology expertise for bench-to-bedside translation. While specific advising details and grant information are absent from the text, her active publication record and group leadership indicate ongoing mentorship of junior researchers and substantial external funding support.
