Yanli Li

Dr. Yanli Li is a researcher at the Division of Immunology and Infectious Diseases, Australian National University. Her work focuses on viral immunology, vaccine development, and infectious disease dynamics in both human and veterinary contexts. She specializes in studying host-pathogen interactions, particularly with Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), Chlamydia trachomatis, and other pathogens.

• Research Themes:
• Innate and adaptive immune responses to viral infections
• Antigen discovery for vaccine design (e.g., CPAF, OmcB)
• PRRSV transmission dynamics and control in swine populations
• CD4+/CD8+ T-cell biology in persistent infections
• Impact of maternal immunity on viral vertical transmission

Recent work emphasizes the failure of viral-vectored vaccines to enhance protection against Chlamydia muridarum, the role of systemic CD4 T-cells in preventing PRRSV transplacental infection, and the evolutionary pressures driving PRRSV variant selection in farm settings. Her studies often integrate computational models (e.g., attention-aware differential learning for peptide-MHC prediction) with experimental immunology.

Dr. Li is registered to supervise research students and has published extensively on swine immune responses, viral antigenicity, and vaccine efficacy under real-world conditions. Her work bridges basic immunology with translational applications in veterinary medicine.