معرفی
Pauline Speder is a Researcher and Head of Structure at the Institut Pasteur in Paris, France, within the Department of Membrane, Cytoskeleton and Cell Division. She leads the research team focused on Brain Plasticity, investigating how neural stem cells and their microenvironment respond to environmental stimuli such as infection and malnutrition using Drosophila melanogaster as a model organism.
- Education: PhD from Institut de Biologie Valrose, Nice, under Dr. Stéphane Noselli; Postdoctoral training at the Gurdon Institute, University of Cambridge, in the laboratory of Prof. Andrea Brand.
Her research centers on developmental neurobiology and stem cell biology, particularly the dynamics between neural stem cells, glial niches, and the blood-brain barrier. She explores how systemic and local cues remodel the neural stem cell niche during neurogenesis and how pathogens breach the blood-brain barrier. Her work integrates genetics, live imaging, and molecular biology to understand brain plasticity in health and disease.
Her recent publications (2011–2023) show a consistent focus on Drosophila models to study neural stem cell regulation, left-right asymmetry, glial niche morphogenesis, and host-pathogen interactions. Key themes include nutrient signaling, blood-brain barrier integrity, and cellular adhesion in neural development. Her articles appear in high-impact journals such as Science, Nature Communications, PLoS Biology, and Developmental Cell.
She has received no explicitly mentioned scientific awards in the provided text.
Pauline Speder mentors several students and researchers, including PhD candidates and postdoctoral fellows. She is Principal Investigator (PI) of the ongoing "Brain plasticity" project and a new project on Toxoplasma gondii. She collaborates within transversal initiatives such as the IP Stem Cell Initiative and LabEx Revive, focusing on regenerative biology and medicine. Her team includes technicians and administrative staff, indicating a well-structured research group.
She is actively involved in research labs and teams at the Institut Pasteur, particularly in studying the neurogenic niche, host-pathogen interactions, and brain connectivity. Her lab uses advanced techniques including confocal microscopy, CRISPR, RNAi, and live imaging.
