معرفی
Professor Paul Lehner holds the Sheila Joan Smith Professorship of Immunology at the University of Cambridge within the Department of Medicine (CITIID). As an active Infectious Diseases Physician, he bridges clinical practice with fundamental research in immunology and virology. His laboratory is situated at the Cambridge Biomedical Campus, contributing to the Cambridge Immunology Network as a Principal Investigator and clinician-scientist.
Lehner's research program centers on virus-host interactions with particular emphasis on epigenetic mechanisms of viral silencing. His group's landmark discovery of the human silencing hub (HUSH) complex represents a major advance in understanding how cells defend against retroelement invasion through genome-wide surveillance. His work integrates proteomics, CRISPR screening, and advanced cell models to investigate antigen presentation, MHC biology, and immune regulation pathways. Recent investigations span from fundamental epigenetic mechanisms to translational applications including SARS-CoV-2 pathogenesis and Long Covid immunology.
Analysis of his publication trajectory reveals consistent focus on viral immune evasion strategies, with growing emphasis on organoid models for respiratory diseases and novel host factors in viral entry mechanisms. His work demonstrates strong integration of basic molecular mechanisms with clinical immunology, particularly evident in recent studies on T cell responses in Long Covid and viral modulation of host proteostasis.
Lehner's research program operates at the intersection of immunology, virology, and epigenetics, maintaining strong clinical connections through his Infectious Diseases practice. His laboratory employs cutting-edge techniques including CRISPR screening, advanced proteomics, and novel organoid models to investigate fundamental mechanisms of immune recognition and viral countermeasures.
