Paul F Lindholm

Paul F Lindholm, MD is a Professor and Director of Hemostasis in the Department of Pathology at Northwestern University Feinberg School of Medicine, specializing in transfusion medicine, hemostasis disorders, and prostate cancer research with significant contributions to platelet function testing and cancer cell invasion mechanisms.

Education:

• MD: University of Minnesota (1983)
• Residency: Univ. of Minnesota Hospital & Clinic, Pathology and Laboratory Medicine (1988)
• Fellowship: National Cancer Institute, National Institutes of Health, Molecular Virology (1994)

Research Focus: Dr. Lindholm's primary research spans hemostasis/thrombosis and prostate cancer biology. His hemostasis work demonstrates that reversing antiplatelet therapy improves outcomes in intracerebral hemorrhage patients, utilizing ROTEM viscoelastic testing and platelet function assays. In cancer research, he identified RhoA/NF-κB pathways driving prostate cancer invasion through monocyte cross-communication involving MCP-1 cytokines.

Publication Trends: Recent work (2024-2025) emphasizes clinical hemostasis applications, including red blood cell transfusion optimization, biomarkers for hematoma expansion prediction, P2Y12 inhibitor impacts on stroke, and RhD phenotype management strategies, reflecting translational focus on improving bleeding disorder treatments and transfusion safety.

Awards:

• Co-Investigator, Northwestern Medicine Academy for Quality and Safety Improvement (2022)
• CHilled Platelet Study (CHIPS), Sub-Investigator (2022)
• Quality Practices Committee Service Recognition, College of American Pathologists (2021)

Grants & Collaborations: Leads NIH-funded studies on intracerebral hemorrhage biomarkers with Drs. Naidech and Kwaan, demonstrating platelet dysfunction links to hemorrhage expansion. Previously managed national grants investigating prostate cancer invasion mechanisms and tumor microenvironment interactions, with ongoing projects on antiphospholipid antibodies with Dr. Ming Zhao.

Laboratory & Teams: Directs Northwestern's hemostasis laboratory performing platelet function assays and ROTEM testing for bleeding disorder management. Contributes to transfusion medicine initiatives evaluating thrombosis risk factors, coagulation factor replacement, and innovative platelet transfusion protocols through collaborations with the College of American Pathologists and Hemostasis and Thrombosis Research Society.