Paul Carey

Paul Carey is a Professor in the Department of Biochemistry at Case Western Reserve University’s School of Medicine. His research focuses on advancing Raman spectroscopy techniques to study enzyme-substrate interactions, particularly in enzyme crystals and live bacterial systems. Key areas include drug resistance mechanisms, RNA ribozyme chemistry, and metal binding dynamics. He has pioneered Raman crystallography for visualizing reaction intermediates in biomolecules such as RNA polymerases and β-lactamases.

Education:

• Doctor of Philosophy, University of Sussex
• Postdoctoral Research, National Research Council of Canada

Research Interests: Carey’s lab integrates Raman microscopy with crystallography to probe molecular-scale biochemical processes. Recent work includes real-time monitoring of drug interactions in bacterial cells and time-resolved studies of RNA synthesis. Techniques like Raman difference spectroscopy and isotope editing enable detailed structural analysis of transient enzyme-substrate complexes.

Article Trends: Publications emphasize antibiotic discovery, enzyme inhibition mechanisms, and structural insights from crystalline systems. Key topics span β-lactamase inactivation, biofilm chemistry, and Raman-based approaches to studying high-molecular-weight biomolecular complexes.

Grants/Advising: While specific grants are unspecified, his work reflects sustained funding for interdisciplinary structural biology research. No formal student advisee list provided in source text.

Labs/Teams: Leads the Carey Lab at Case Western Reserve, collaborating with institutions like the National Research Council Canada and Cleveland’s Case Comprehensive Cancer Center.