Paul Besseling

Dr. Paul Besseling is a Research Fellow in Biomedical Engineering at Eindhoven University of Technology, specializing in cardiovascular tissue regeneration. His work focuses on developing biodegradable vascular grafts that transform into living blood vessels through in situ tissue engineering approaches.

Research Innovations:

• Development of off-the-shelf synthetic grafts for arteriovenous fistula creation
• Integration of iPSC-derived vascular organoids with scaffold-based engineering
• Investigation of disease impacts on vascular tissue regeneration

His multidisciplinary research combines biomaterial science, cell biology, and pre-clinical modeling to address challenges in vascular access for hemodialysis patients. Recent publications demonstrate the successful transformation of supramolecular polymer grafts into functional blood vessels in large animal models.

Laboratory Expertise:

• In vitro biocompatibility assessment of biomaterials
• Chronic kidney disease models for tissue engineering validation
• Functional evaluation of vascular grafts under physiological flow conditions