Panagiotis Marakos

Professor Panagiotis Marakos serves as a faculty member in the Department of Pharmaceutical Chemistry at the Faculty of Pharmacy, National and Kapodistrian University of Athens.

His academic credentials include:

• Degree in Pharmacy (1982) from the Department of Pharmacy, National and Kapodistrian University of Athens
• PhD in Pharmaceutical Chemistry (1987) from the Department of Pharmacy, National and Kapodistrian University of Athens

Professor Marakos's research centers on the design, synthesis, and pharmacological evaluation of novel compounds as potential cytotoxic and antiviral agents. His expertise spans medicinal chemistry with emphasis on heterocyclic compound development, including pyrazolopyridines, purine analogues, and pyrrolopyrimidines. His work integrates chemical synthesis with biological testing to target cancer mechanisms and viral replication pathways.

Analysis of his 2016-2019 publications reveals a dominant focus on anticancer drug discovery, particularly through kinase inhibition (EGFR, PI3Kα), angiogenesis suppression, and senescence induction. His research also extends to antiviral development targeting HCV via NS5A inhibition and innovative cardioprotective strategies using hydrogen sulfide-releasing hybrids. The interdisciplinary approach combines transcriptome analysis, molecular docking, and pharmacokinetic studies to validate mechanisms of action.

Teaching responsibilities encompass undergraduate courses 'Pharmaceutical Chemistry II' (6th semester), 'Pharmaceutical Chemistry IV' (8th semester), and laboratory instruction in pharmaceutical chemistry techniques, plus graduate-level 'Advanced Medicinal Chemistry'.