Nikhil Joshi

Nikhil Joshi is an Associate Professor in the Department of Immunobiology at Yale University, with affiliations to the Yale Cancer Center and Yale Center for Immuno-Oncology. His research focuses on T cell immunology in cancer and infection contexts.

• Yale Cancer Center
• Yale Center for Immuno-Oncology
• Human and Translational Immunology Program

Research Interests: The Joshi laboratory investigates immune cell interactions with developing tumors using complex mouse models. They study T cell differentiation in cancer and infection, focusing on peripheral tolerance mechanisms, tumor microenvironment dynamics, and therapeutic modulation of immune responses.

Publication Trends: Recent work spans cancer immunotherapy models (2025), KLF2 regulation in T cell exhaustion (2025), single-cell gene mapping (2024), tertiary lymphoid structures (2024), and immunometabolism (2024). Earlier publications established neoantigen systems (2020) and tissue-specific tolerance models (2018).

Scientific Awards:

• Class of 1961 Cancer Research Award
• Basic Science Research Prize
• Pershing Square Sohn Prize
• Emerging Leader Award
• James B. Dougherty MD Award

Lab & Collaborations: The Joshi Lab at Yale's Anlyan Center develops advanced tumor models. They collaborate with computational biologists, clinical teams, and immunology researchers to bridge fundamental discoveries with translational applications.