Michael Chiorazzi

Michael Chiorazzi, MD, PhD, is an Assistant Professor of Internal Medicine (Medical Oncology) at Yale School of Medicine, with appointments in Medical Oncology and Hematology. He is affiliated with the Yale Cancer Center and the Janeway Society, underscoring his role as a physician-scientist in oncology and immunology research. His work bridges clinical medicine and basic science, focusing on cancer immunology and the tumor microenvironment.

• Assistant Professor of Internal Medicine (Medical Oncology), Yale School of Medicine
• Post-Doctoral Fellow, Immunobiology, Yale School of Medicine (2019)
• Fellow, ABIM Research Pathway, Hematology & Medical Oncology, Yale (2018)
• Resident, ABIM Research Pathway, Internal Medicine, Yale (2014)
• PhD, The Rockefeller University (2012)
• MD, Cornell University Medical College (2012)
• BA, Biology, Williams College (2002)

Dr. Chiorazzi's research focuses on cancer immunology, particularly the interactions between immune cells and tumors. His work explores the tumor microenvironment, immune evasion mechanisms, and metabolic adaptations of T cells in cancer. He employs humanized PDX models and transcriptomic analyses to study immune responses in immuno-oncology. His studies have contributed to understanding CD8+ T cell function, macrophage heterogeneity in melanoma, and platelet-mediated immunosuppression.

His recent publications span high-impact journals such as the Journal for ImmunoTherapy of Cancer, Journal of Experimental Medicine, and Cancer Cell. These works reflect a strong trend in translational immunology, integrating genomics, cell biology, and clinical oncology to advance cancer immunotherapy. Themes include T cell metabolism, tumor-immune interactions, and molecular mechanisms of lymphoma.

Dr. Chiorazzi collaborates extensively with leading immunologists, including Richard Flavell, Esen Sefik, and Jing Du. His research is supported by institutional affiliations with Yale Cancer Center and the Immunobiology program. While no specific grants are listed, his postdoctoral and clinical research pathway training indicate sustained funding support for physician-scientist development.

He maintains an active laboratory at Yale, located at the Anlyan Center, and is involved in training and mentoring within the medical and graduate education programs. His work contributes to both fundamental immunology and clinical translation in oncology.