Neil A. Mabbott

Neil A. Mabbott is a Professor at the Royal (Dick) School of Veterinary Studies, University of Edinburgh, UK, where he leads research at the intersection of immunology and neuroscience. His work spans neurodegenerative diseases, particularly prion pathologies, with strong collaborations across the University of Edinburgh ecosystem including The Roslin Institute and SRUC.

His research program focuses on neuroimmune mechanisms in aging and disease pathogenesis. Key investigations include:

• How peripheral immune challenges (e.g., LPS exposure) modulate susceptibility to prion infections
• Microglial repopulation dynamics in brain disorders
• Host-pathogen interactions at mucosal barriers
• Neuropathological consequences of genetic mutations like Csf1r

These studies integrate immunology, neuroscience, and infectious disease models to unravel neurodegenerative mechanisms.

Recent publications (2024-2025) reveal a cohesive trajectory in neuroinflammation research, with emphasis on microglial function, astrocyte activation, and genetic determinants of brain pathology. His work bridges fundamental immunology with clinical neuropathology, particularly in prion diseases and leukoencephalopathies.

No scientific awards are documented in the available information.

Prof. Mabbott maintains an active grant portfolio evidenced by continuous high-impact publications and extensive collaborations (496+ co-authors). While specific funding sources aren't detailed, his research requires substantial resources for in vivo modeling and neuropathology analysis. Current student supervision details aren't provided, though his Professorship implies graduate mentorship responsibilities.

His research group operates within the Royal (Dick) School of Veterinary Studies infrastructure, utilizing advanced techniques in cellular immunology and neurobiology. The collaborative environment with The Roslin Institute provides access to cutting-edge genomics and imaging facilities for studying brain-immune interactions.