Jakob Matschke

PD Dr. Jakob Matschke is a researcher at the Institute of Neuropathology of the University Medical Center Hamburg-Eppendorf (UKE). With over 187 publications, his work spans critical areas in neuropathology, neuroimmunology, and neurodegenerative diseases.

• Current Affiliation: Institute of Neuropathology, UKE
• Research Themes: Brain tumor biology, post-COVID-19 neurological effects, prion diseases, immune-tumor interactions, and neurodegenerative tauopathies

His research on malignant gliomas explores somatic mutations in HLA class genes and antigen presentation mechanisms, while recent studies on SARS-CoV-2 examine neuroinflammatory scars and blood-brain barrier dysregulation. Collaborations include teams in clinical immunology (C3i) and the Neuro-Immune Network Hamburg.

Key trends in his 15 most recent articles (2022-2025) include:

• Neuro-oncology: Tumor growth kinetics, glioblastoma survival disparities, spinal cord tumors
• Neuro-immunology: CD4 T cell responses, MPXV immune evasion, post-COVID-19 microglial activation
• Neurodegeneration: Prion protein shedding, TDP-43 cross-seeding, anti-IgLON5 disease pathology

Prominent methodologies involve epigenomics, spatial immune mapping, and RT-QuIC assays for prion detection. His work often intersects clinical case studies with translational research, particularly in postmortem analyses of infectious and degenerative neurological conditions.