NG Huck Hui

NG Huck Hui is a Research Professor and Senior Group Leader at the Laboratory of Precision Disease Therapeutics, Genome Institute of Singapore (GIS), under A*STAR. His research focuses on stem cell biology, particularly on understanding and harnessing the potential of pluripotent and adult stem cells for regenerative medicine and disease modeling. Key interests include stem cell state maintenance, controlled differentiation for 3D cellular models, and applications in neurodegenerative and metabolic diseases.

He leads a team developing advanced genetic and cell culture approaches to create biologically accurate disease models, aiming to advance personalized medicine. His work emphasizes creating functional organoids (e.g., midbrain organoids with dopaminergic neurons) and mini-brains for studying complex disorders.

Recent publications highlight innovations in stem cell reprogramming, transcriptional networks (e.g., Oct4/Nanog), and regulatory mechanisms governing pluripotency. He actively recruits postdoctoral fellows and students to expand this research.

His laboratory collaborates across disciplines to bridge basic science with translational applications, focusing on leveraging stem cells for therapeutic discovery and disease understanding.